An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c3cc43457e Click here for additional data file. Click here for additional data file.
نویسندگان
چکیده
19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.
منابع مشابه
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